Satellite Symposia
Organizing Company: IRTA (academy) and LUCTA SA (industry)
Title of symposium: Impact of stress on the physiological status of the pig
Date and time: Tuesday 17 May, 13:00-16:00 PM
Symposium summary
Aim: Provide a comprehensive review of the latest scientific advances in the field of gastrointestinal function, and how homeostasis is compromised by stress. Global academic experts will be invited to present research on digestive function, physical and immunological gut barrier, gut microbiome, and efficiency in relation to stress. This knowledge will be put in context of the main stress‐related challenges currently affecting the pig industry by experts at the frontier of industry‐academia. Ultimately, it is hoped that the symposium will generate discussion and provide guidance towards optimized strategies to tackle some of the main issues affecting pig commercial production and welfare.
Chairman: Dr. David Torrallardona (IRTA)
Duration: 2.5 hours
AGENDA
Welcome and Introduction of the Satellite
Dr. David Torrallardona (IRTA) / Dr. Gemma Tedó (LUCTA SA)
1. The role of fibre and protein fermentation in digesta transit, digestion, and gastrointestinal health
Dr. Sonja de Vries (Wageningen University)
2. The long reach of early life stress: Impact of early weaning on programming of intestinal and immune function
Prof. Adam J. Moeser (Michigan State University)
3. Microbial endocrinology as a mechanism governing the interplay between host and microbiota during stress ‐ its role in gut health and behavior in pigs
Prof. Mark Lyte (Iowa State University)
4. The fantastic feed efficiency of newly weaned piglets: a sign of efficiency or deficiency?
Dr. Theo van Kempen (Trouw Nutrition – North Caroline State University)
5. Evaluation of the gastrointestinal tract “resilience” to stressors in pigs
Dr. Gemma Tedó (Innovation Division, LUCTA SA)
Concluding remarks
Dr. David Torrallardona (IRTA)
Organizing Company: ANIMINE
Title of symposium: Zinc and copper metabolism: a holistic approach for swine nutrition and health
Date and time: Tuesday 17 May, 13:00-16:00 PM
Symposium summary
Trace minerals are essential elements added to every single diet formulated in the world.
Zinc (Zn) is playing and important role on the immune response, the activity of digestive
enzymes and the morphology of the digestive tract. Copper (Cu) is involved in processes concerning iron utilisation and synthesis of haemoglobin and connective tissue.
After weaning, the inclusion of high amounts of Zn in diets for piglets has an inhibitory effect on the incidence and severity of unspecific diarrhea and a positive effect on weight gain.
Nonetheless, the evidence behind these beneficial effects remains to be demonstrated.
Cu has been used as a “growth promoter” in pig production for several decades. Few hypotheses have been proposed to explain the growth promoting effect of dietary Cu in relation to the gut function (modulation of the microflora or an effect on morphology and turnover of enterocytes) or in relation to systemic effect within the body (hormonal regulationor lipids´ metabolism) but the real mechanism(s) of action remain a matter of controversy.
The prolonged use of Zn and Cu at high concentrations promote selective pressure on bacteria and, for this reason, spread of resistance to antibiotics of gut bacteria in pigs. Besides bacterial resistance, the accumulation of both Zn and Cu in the soil is a growing societal concern in many countries.
This satellite symposium around copper and zinc has the intention to update and scientific knowledge and to foster discussions with reputed scientific experts in the field of trace minerals and swine nutrition from the USA and Europe.
PROGRAM
Copper session
Effects of dietary copper on hormonal, neurological and intestinal axes as potential mechanisms of action.
Dr. Paul Bikker, Wageningen University
Interactions between copper and lipid digestibility.
Dr. Alessandra Monteiro, Animine
Zinc session
State of the art on the effect of ZnO on health and performance of weaned pigs.
Prof. Paolo Trevisi, University of Bologna
Zinc oxide and the gut of pigs: Still a miracle? Facts, mode of action, alternatives.
Prof. Jürgen Zentek, Freie Universität Berlin
ZnO supplementation in antibiotic-free piglet diets : a Chinese experience
Prof. Yulong Yin, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha
Moderator of the session: Jennifer Maurin, Animine Marketing & Sales director
Organizing company: Metex Noovistago
Title of symposium: Dietary amino acids in feed intake and growth in pigs: the gut-hypothalamus and the liver-muscle axes
Date and time: Tuesday 17 May, 09:00-12:00 AM
Symposium summary
While energy has been identified as the main driver in feed intake, recent advances in digestive physiology show that the sensing of amino acids activating the gut-hypothalamus axis may be the most critical in influencing short- and long-term appetite in pigs. In addition, the amino acid cycle between liver and muscle orchestrates protein accretion (and growth).
The mediators of the dialogue between amino acids and body functions are receptors, transporters, and transceptors located in the apical membrane of enteroendocrine cells (EEC) that orchestrate the hunger-satiety cycle.
Cell responses include the release of more than 20 different types of hormones in response to nutrients.
The concept of ‘one cell – one hormone’ has been abandoned adding another layer of complexity to understand the control of feed intake. In addition, abundance or deficiency of amino acids can be sensed by protein kinases (GCN2, mTOR, AMPK) directing protein synthesis in liver and muscles.
These research areas are two of the most active in physiology and have delivered ground-breaking advances in recent years.
This Satellite Symposium will bring to the DPP community an update of the most important advances in amino acid metabolism relevant to pig nutrition by highlighting a double axis of metabolic implications: the gut-brain and the liver-muscle.
Organizing Company: MetaPig – CANCELED
Title of symposium: Exploiting the pig gut microbiota for better and more sustainable pig production
Date and time: Tuesday 17 May, 09:00-12:00 AM
Conventional pig production is challenged by the increasing demands for reducing the use of antibiotics and the impact on the environment. The importance of the pig gut microbiota in relation to metabolism, health and diseases is now well recognized, and targeted knowledge-based modulation of the pig gut microbiota may offer possibilities to reduce diseases and environmental impact. Here we will present the results from the MetaPig project supported by the Innovation Fund Denmark aiming to modulate the pig gut microbiota to increase feed efficiency and gut health. In this project we integrate cutting-edge knowledge on pig farming, pig feed, pig genomics, metagenomics and systems biology with the goal to decipher how feed composition or feed additives affect gut microbiota composition and function, feed efficiency, gut health, and gut microbiota–host genome interaction. The project takes advantage of the work performed by members of the consortium establishing a reference pig genome and gut metagenome by using Next Generation Sequencing and novel bioinformatics algorithms, and combine this with unique knowledge of Danish pig farming and pig feed production. Thus, the project aims to identify assemblies of bacteria and/or single bacteria characterizing a gut microbiota, which supports both high feed efficiency and gut health. In addition, the project aims to elucidate the interaction between the host genome and the gut microbiota. By combining all information, the project aims to provide information as to how it will be possible to push the gut microbiota towards a desired composition by targeted feeding or cost-effective supplementation to optimize host-metagenome interaction supporting gut health and a more sustainable pig production. In this satellite symposium we provide overviews on 1) the current knowledge of the composition and function of the pig gut microbiota, 2) how different types of pig feed modulate the composition and function of the gut microbiota, 3) how farm conditions influence the gut microbiota and productivity, 4) how these changes are influenced by pig genetics and affect the function of the gut mucosal lining, and 5) how the composition of the gut microbiota impinges on resistance to disease.
Lectures:
Karsten Kristiansen, Department of Biology, University of Copenhagen, Denmark and the Institute of Metagenomics, Qingdao-Europe Advanced Institute for Life Sciences, Qingdao, China: “The pig gut microbiome, composition and functional potential”.
Emil Ibragimov, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark: “Analysis of merged transcriptomic and genomic datasets to identify genes and pathways underlying residual feed intake in growing pigs.”
Nuria Canibe: Department of Animal Science, Aarhus University, Denmark. “Impact of feed additives on gut microbiota in pigs and level of engraftment after microbiota transplantation.”
Simon Roques University of Wageningen, Wageningen Livestock Research, The Netherlands: “Relationship between fecal microbiota composition and performance in growing pigs as affected by environmental conditions.”